Interstate 75

Pre-Apocalypse
Before the outbreak, the interstate functioned as a regular highway, and connected the north and south of the country.

Post-Apocalypse
During the outbreak, the highway, like many others, became congested with traffic as many people tried to get to the cities.

Season 1
Rick uses this highway to get to Atlanta from his home town of Cynthiana.

Users

 * Rick Grimes
 * Lori Grimes (Assumed)
 * Carl Grimes (Assumed)
 * Shane Walsh (Assumed)
 * Many unnamed people

Deaths

 * Numerous counts of unnamed people

Season 1

 * Days Gone Bye